Obesity is an illness which is harder to treat than many cancers. Doctors and patients have been buying medicinal approach coupled with proper nutrition and regular exercises to cope with chronic weight problems. One of the most popular drug for that objective is phentermine.
Once widely praised as a "wonder drug", phentermine still offers as the most commonly prescribed appetite suppressant in the US, one of the reason being the cheaper price compared to other similar drugs.
Phentermine enhances the levels of several neurotransmitters including dopamine and norepinephrine affecting blood vessels flow, heartbeat, and reactivity to stress. This will make people eat more rapidly but to eat less. Another appetite suppressant, fenfluramine, acts on a different neurotransmitter, serotonin. Serotonin is involved in handling mood and reduces the feelings of agitation associated with hunger.
Phentermine is a generic name, which is sold under various brandnames including Ionamin, Adpex-P, Fastin, etc. phenq Phentermine first became available for consumers in the late 50s, and later modified as Phentermine Hydrochloride (HCl) in the 70s.
Phentermine became popular again in the 90s as 'cocktail', Fen-Phen. Within 1992, Dr. Weintraub from University of Rochester Institution of Medicine and Dentistry published a paper with a study that Fen-Phen works more effectively than diet or exercise in long-term obese cases. Fen-Phen became an overnight sensation.
Although phentermine and fenfluramine are both approved by FDA separately, their mixture, 'Fen-Phen' never was, and their prescription by doctors was considered "off-label".
Dexfen-Phen is another combination including phentermine. In this case, the other ingredient is dexfenfluramine or redux. Dexfenfluramine was also used as a possible appetite suppressant. Dexfen-Phen again followed the suit, and became widely popular.
In 97, Mayo Clinic reported twenty four cases of heart valve disease in the patients who had taken fen-phen drink. Further findings suggested fenfluramine and dexfenfluramine may be related to heart control device disorder, and accordingly, FDA issued a public health advisory and requested drug manufacturers to voluntarily pull away fenfluramine and dexfenfluramine.
In contrast to fenfluramine and dexfenfluramine, phentermine was not taken off the market. Phentermine is again used in various drink forms. It was necessary since phentermine's appetite controlling effect decreases rather rapidly over time.
Among the new cocktail involving phentermine is "Phen-Pro", phentermine plus prozac, a popular antidepressants. Phen-pro cocktail makes phentermine work longer and has no significant psychological effect.